MAGNETIC HYPERTHERMIA

CANCER TREATMENT

STEM CELL GENE THERAPY

2026

Magnetic Hyperthermia: (In Vitro / In Vivo Cancer Research)

(1) Targeting

(2) Trigger Release

(3) Heat Penetration

(4) Intracellular Heating

Comparative DOX Delivery Paradigms for Heat Responsive Liposomes

Summary: The key difference between the tumor models is vascular permeability. Temperature triggered drug release and simultaneous hyperthermia heating increased microvascular permeability and drug infusion by 9-fold. M. Dewhirst, NanoScale Drug Delivery and Hyperthermia, 2011.

Magnetic Hyperthermia / Nanoparticle Heating

Gene Therapy / Cancer Research

Features:

1. Heating Power: 5.0-7.0 KW / 150-450 kHz / 500-900 kHz
2. Magnetic Power Intensity: (350-1400 Gauss / High SAR values)
3. Round Heating Coils: 40-130 mm / Helmholtz Heating Coils
4. Hand-Portable Planar Magnetic Amplifier: 35-55 mm tissue depth penetration

TECHNOLOGY REPORT: The physiology of the tumor is one of the key factors responsible for the failure of chemotherapy: (1) High hydrostatic pressure of tumors and limited blood flow prevents drugs to easily penetrate tumor tissue rich with cancer cells. (2) Cancer cell’s cumulative resistance to repetitive drug treatments. (3) Damaging effects of drug toxicity on non-targeted and healthy tissue. (4) Absence of a useful system to remotely trigger the release of the cancer drug specifically at the site of the tumor.

MAGNETIC HEATING of temperature sensitive magnetic nanocarriers allows targeted release of the cancer drug. (P. Pradhan) Further, low temperature heating can improve microvascular permeability of the tumor. This allows the drug to more easily penetrate the cancer tissue and restrict the growth of the tumor. (M. Dewhirst)

Hand Portable Magnetic Heating Device—Focused Heat

The Magnetic Heating Device can be held over the tumor area for 1-30 minutes. Healthy tissue is not affected by the magnetic field. The magnetic heating force is a function of the frequency and the magnetic field amplitude. The computer automatically maintains the magnetic heating effect at or below the FDA guidelines for RF heating. (Patent Pending.)

Getty Image

Treating Multiple Myeloma is a serious skin condition. The hand unit is useful to apply the heating to the area that suffers from the virus or infection.

Treating Foot Ulcers: Foot Ulcers (DFU) begin as a minor infection and can progress to fully infect the foot despite antibiotic treatment. The reasons are simple: (1) Antibiotics struggle to keep up with constantly mutating drug-resistant bacterial infections. (2) Bacterial Biofilm degrades and blocks the antibiotics from penetrating the infection. (3) Peripheral Vascular Disease blocks the blood flow to deliver the antibiotics.

Magnetic Heating does not suffer from any of the problems of antibiotics. In particular, antibiotics cannot penetrate the bone. Bone infections typically result in the need for amputation to save the patient from sepsis and death. Magnetics penetrates the bone easily and attacks the infection.

Breakthrough in Magnetic Hyperthermia Treatment

(Treating Gioblastoma: An aggressive and fatal cancer)

Hand Portable Heating Device: Cancer research has used magnetic hyperthermia to enhance the effectiveness of chemotherapy. Conventional treatments have used over-sized round magnetic heating coils to encompass the entire skull. This fails because the magnetic field is too weak and heating is insignificant. The use of a portable hand unit with a flat planar coil has a far higher possibility of success. The hand unit can apply significant heating in specific areas of the skull. Heating is controlled in a 70 mm diameter pattern and penetrates 30-40 mm into brain tissue. It is an alternative treatment when the remaining options are debilitating chemo and risky brain surgery.

Brain Tumors can be treated with chemotherapy and surgery. But the cancerous lesions are difficult to remove through surgery. Employing nanoparticles and magnetic hyperthermia offers an additional method to stop the spread of the tumor.

Treating Breast Cancer is not much different than treating infant brain cancer. The heating coil can be shaped in a Cup-Format to encompass the tissue and to be centered over the location of the tumor. Or, a PLANAR Coil can be pressed against the breast to deliver heating a short distance to the tumor.

The Unmentioned Truth of Chemo Therapy is that the doctor will use only enough chemo that has a chance to stop the cancer and without injuring the health of the patient. A larger dosage of chemo might be more effective against the patient’s cancer, but the chemo, itself, is so toxic that it could badly injure the health of the patient.

A Secondary Issue with Chemo is that it reduces the White Blood Count. The White Blood cells fight infections. So there is a probability during Chemo that infections may happen. For diabetics who suffer common foot and leg infections, the toxic combination of Chemo and Antibiotics together may be just too much. WHO reports that 8.5% of all cancer deaths are actually deaths from infections that occurred during cancer treatment. Since magnetic treatment is a non-drug treatment, it does not interfere with the cancer treatment.

Method: As with any drug treatment, chemo therapy puts unusual stress on the health of the patient. The hand unit can be aimed at a tumor to amplify the effectiveness of chemo, sparing the patient from the devastation of full body chemotherapy.

Temperature profile in rising trajectory as soon as magnetic heating applied. Software is provided to display this on the researcher’s laptop computer.

Neoptix Fiber Optic Temperature Sensor is included with each system. Up to 2-4 sensors can be utilized and charted independently.

Shown is a 120 mm Heating Coil with 2 mm Teflon Inner and Outer Sleeves to protect the Animal or Patient's body part if used for Clinical Magnetic Hyperthermia Treatment.

(Steel Rod is inserted to show heating power.)

Coil of this size is used for animal research / treatment potential for infant brain cancer.

Rear of the Cabinet Showing Connections

Rear of the Cabinet: Power Disconnect Switch, Circuit Breaker, Water Inlet and Outlet, Pressure Gauge, Control Cable to Heat Station.

Interface Connections:

1. +24 VDC Auxiliary Supply
2. Fiber Optic Sensors (2)
3. Magnetic Field Sensor
4. USB Port
5. Type J Thermocouple Socket
6. External Control Cable Socket
7. RS-232 / RS-485 Ports.
8. Aux.

SPECIFICATIONS:

• POWER LEVELS AVAILABLE: 5.0, 7.0, 10.0 and 12.0 KW
• AC VOLTAGE: SINGLE PHASE 208-240 VAC 50/60 Hz / THREE PHASE: 240-480 VAC / 20-30 AMPS
• AVAILABLE FREQUENCY RANGE: 100-500 KHZ (100-800 KHZ OPTIONAL)
• WATER COOLING: 12 LITERS/MINUTE @ 2 BAR (30 PSI)
• WATER CHILLER: 8000 BTU

DIMENSIONS

• POWER SUPPLY: 27.5” (60 cm) Length x 14.5” (35 cm) High x 21” (50m) Wide / Weight: 120 LBS. (60 kilos)
• HEAT STATION: 10” (25 cm) Wide x 12” ((30 cm) High x 18” (45 cm) Long / Weight: 40 lbs. (20 kilos)
• CABLE BETWEEN POWER SUPPLY AND HEAT STATION: 1-2 METER
• SOLENOID HEATING COIL DIAMETER: 40-80 mm (STANDARD) / 90-110 mm (LARGER SIZES ARE AVAILABLE)
• HAND UNIT PLANAR COIL: 50 mm DIAMETER
• HEAT STATION AND HAND UNIT SELECTOR SWITCH

USER INTERFACE / COMMUNICATION:

• COLOR TOUCH SCREEN / LOCAL OR REMOTE CONTROL
• DIGITAL CYCLE TIMER / BUILT INTO THE TOUCH SCREEN
• DIGITAL TEMPERATURE CONTROLLER / RS-485
• ETHERNET CONNECTION TO REMOTE LAPTOP COMPUTER / EASYLINK SOFTWARE (AVAILABLE)
• TEMPERATURE MEASUREMENT PROBE: SINGLE OR DUAL
• TEMPERATURE MEASUREMENT SOFTWARE: NEOPTIX OPTILINK AND RS-232 CABLE INCLUDED

MSI AUTOMATION, INC.

8537 GreenBriar St., Wichita, Kansas 67226 USA

316-796 4110 / Email: DAVE@MSIAUTOMATION.COM

Web Site: WWW.MSIAUTOMATION.COM

International Representatives:

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