SYNERGY

ANTIBIOTICS

(ATTACKS THE BACTERIA CELL WALL)

+

MAGNETIC HYPERTHERMIA

(HEATS THE BACTERIA CELL FROM THE INSIDE. CELL WALL WEAKENS AND RUPTURES)

=

COMBINATION

ANTIBIOTICS+MAGNETICS ALLOW THE IMMUNE SYSTEM TO CLEAR THE INFECTION

MSI AUTOMATION, INC.

2026

To Improve Infection Treatment

Diabetes

Technology: The growing antimicrobial resistance (AMR) to antibiotic treatment for infections is evident worldwide (WHO). Once a drug resistant is present in a diabetic infection, it rapidly populates the infection, using excess glucose to accelerate growth. In contrast, Magnetic Hyperthermia causes the bacteria to self-heat and die. Infections that resist antibiotic treatment, (staphylococcus, etc…), can be eliminated.

Magnetic Hyperthermia exploits the biosynthesis of iron that bacteria use for its own metabolic processes. This Magnetic Heating (AMF) causes the bacteria cell’s iron nanoparticles to self-heat. Cell death follows. Dynamically, the AMF can penetrate the bacterial biofilm and also bypass the peripheral vascular disease to open a wide pathway for the antibiotics to reach the infection. Amputation: a serious, costly, and too common possibility for diabetic patients: is avoided.

Computer Control: The computer controls the heating power at or below the FDA limit, allowing for safe operation. (Patent Pending)

Hand Unit (above) or the Foot Insertion Module are designed to treat Foot and Lower Limb Infections. AMF heating penetration is up to 50 mm.

LEG INFECTIONS: Magnetic Hyperthermia is a key treatment for leg infections.

This Foot Infection was treated with antibiotics but the infection continued.

HUMAN TISSUE HUMAN BONE

E-Coli Infection E-Coli Infection

BEFORE AMF BEFORE AMF

Tissue samples taken from live patients whose infections spread despite antibiotic treatment. (C) E. Coli infected muscle sample. (D) E.Coli infected bone sample. Both treatments were exposed to magnetic hyperthermia heating (AMF) for 5-15 minutes. Longer exposure results in higher death rate for the bacteria. Scanning electron microscope images revealed the destruction of the bacterial cell wall. AMF treatment also resulted in excess reactive oxygen species formation, which might contribute to bacteria cell death. (As required by the FDA: A lengthy safety study of 25 female rats showed an overall lack of significant edematous response to AMF.)

SYNERGY: Magnetic Hyperthermia(RF)

Enhances Antibiotic Treatment

1. Antibiotics is not the cure-all and is toxic to patients already weakened by disease. Some doctors refuse to use it.
   RF kills bacteria, allowing for lower dosage of antibiotics.
2. Hospitals report 30-50% of infections are already drug resistant.
   RF treatment is not a drug and will attack the infection.
3. Antibiotics is blocked by peripheral vascular disease.
   RF attacks the infection without blood supply problems.
4. Antibiotics cause bacterial mutations.
   RF kills the bacteria without causing bacterial mutations.
5. Each Bacteria Strain may need a specific Antibiotic.
   RF attacks the infection regardless of the bacteria strain.
6. New antibiotics can take years and $ millions to arrive.
   RF treatment is successful with all forms of bacteria..
7. Cancer Patients have a weakened immune system that causes infections. Antibiotics used to fight the infection can interfere with the cancer treatment and cause patient death.
   RF treats infections without worsening the patients health.
8. WHO reports 8.5% of all cancer deaths are caused by infections, not the cancer.
   RF delivers rapid and successful infection treatment.
9. Antibiotics cannot penetrate the bone. Leg amputation is certain.
   RF easily penetrates deep tissue and bone and up to 50 mm.

MSI AUTOMATION, INC.
8537 GREENBRIAR ST., WICHITA, KANSAS USA 67226
316-796 4110 WEB SITE: WWW.MSIAUTOMATION.COM-
E.Mail: DAVE@MSIAUTOMATION.COM